How does everyone manage weight gain due to their preventatives? I have gained 40 pounds because of amtripyline but got it to stop by dropping the other ones that weren't doing anything (vaporic acid and tramadol ER). I want to stay on this med because it's the only one that has made any difference to my severe depression and I need it at the 75mg level. But I started taking 30mg of baclofen since a lot of the pain is due to muscle spasms. Now after a week I am up another pound and eating healthy and exercising some (as much as the pain allows me). I really hate it. 🙁