Preventing Migraines with Vitamin D3

Hi Batch,

Thank you for sharing your information with us. I did find your abstract and will post this link here; http://www.neurology.org/content/82/10_Supplement/P1.256.

It seems some of us with migraine and ch are vitamin D deficient. A 2008 study found nearly 42% of people with migraine deficient in vitamin D.

Again, thanks for sharing,
Nancy

I know this is an old post but I’m a new sufferer of CH and I am looking for relief. I am starting this treatment tonight! I’ve seen your posts (Batch) on other sites. I hope this works!!! I don’t know if you’ll see this but thank you for sharing!

Hey toodlebuggoff,

You can find the most recent posted version of the anti-inflammatory regimen at the following VitaminDWiki link. Be sure to discuss it with your PCP so requirements for the needed lab tests are understood.

http://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=7708

Migraineurs need to modify this regimen by increasing the vitamin D3 maintenance dose to 20,000 IU/day and shoot for a target serum 25(OH)D range of 90 to 120 ng/mL. Migraineurs also need to add a tablet a day of CoQ10 and a 1000 mg/day of Turmeric (Curcumin). The 12-Day accelerated vitamin D3 loading schedule at 50,000 IU/day for 12 days is important in getting a good start on this regimen as it elevates serum 25(OH)D rapidly to the therapeutic range. If there's no joy after 3 to 4 days on the 12-Day loading schedule, many headache sufferers have found a week to 10-day course of Benadryl (Diphenhydramine HCL) at 25 mg every 4 hours throughout the day and again at bed time. Just be careful and not drive while taking Benadryl as it will make you drowsy.

When you complete the 12-day loading schedule, drop back to an initial vitamin D3 maintenance dose of 15,000 to 20,000 IU/day. After three weeks at this dose, see your PCP for lab tests of your 25(OH)D, total calcium and PTH. As long as your serum calcium remains within its normal reference range and your PTH stays in the lower third of its normal reference range, the 25(OH)D serum concentration doesn't really matter. As a chronic CHer, I take 20,000 IU/day vitamin D3 and have maintained an average 25(OH)D serum concentration of 140 ±50 ng/mL for the last few years. My PCP is ok with this as long as my serum calcium remains within its normal reference range... and it has...

One of the most important things to do as headache sufferers is drink 2.5 liters of water a day. Taking 2000 to 4000 mg/day of vitamin C is also a good idea. We lost the enzyme needed to produce vitamin C somewhere in our evolutionary history so we need to obtain this important vitamin from supplements or diet. Dr. Linus Pauling took 18 grams of vitamin C a day... He also lived to 93...

Take care and please keep us posted. V/R, Batch

VITAMIN D3 PREVENTS MIGRAINE

When you read the following, consider this... At face value, the following study indicates less than 5 cents a day vitamin D3 (4,000 IU/day) prevents migraine as good as if not better than the leading FDA approved anti-CGRP mAb costing >$700/month.

Take care,
V/R, Batch

Curr Med Res Opin. 2018 Sep 5:1-22. doi: 10.1080/03007995.2018.1519503. [Epub ahead of print]
A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine.
Gazerani P1, Fuglsang R1, Pedersen JG1, Sørensen J1, Kjeldsen JL1, Yassin H1, Nedergaard BS2.
Author information
Abstract

BACKGROUND:
Vitamin D levels have been linked to certain pain states, including migraine. We investigated whether vitamin D supplementation would be beneficial for adult patients with migraine (ClinicalTrials.gov Identifier: NCT01695460).

METHODS:
A randomized, double-blind, placebo-controlled parallel trial was conducted in migraine patients (36 women and 12 men, 18-65 years of age). A 4-week baseline period was conducted before randomization to 24 weeks of treatment. Participants were assigned to receive D3-Vitamin® (n = 24, 18 women and 6 men, 100 μg/day D3-Vitamin®) or placebo (n = 24, 18 women and 6 men). Migraine attacks and related symptoms were assessed by self-reported diaries. The response rate (i.e., experiencing a 50% or greater reduction in migraine frequency from baseline to week 24), change in migraine severity, and number of migraine days were recorded. Changes in migraine-related symptoms, HIT-6TM scores, and pain sensitivity tests (pressure pain threshold and temporal summation) were also evaluated. Serum levels of both 25(OH)D and 1,25(OH)2D were assessed from baseline to week 24.

RESULTS:
The number of headache days changed from 6.14±3.60 in the treatment group and 5.72±4.52 in the placebo group at baseline to 3.28±3.24 and 4.93±3.24 by the end of the trial, respectively. Migraine patients on D3-Vitamin® demonstrated a significant decrease (p < 0.001) in migraine frequency from baseline to week 24 compared with placebo. However, migraine severity, pressure pain thresholds or temporal summation did not show a significant change. 25(OH)D levels increased significantly for the D3-Vitamin® group during the first 12 weeks of treatment. There was no significant change in 1,25(OH)2D. No side effects were reported or noted.

CONCLUSIONS:
D3-Vitamin® was superior to placebo in reducing migraine days in migraine patients. Larger studies are required to confirm that vitamin D3 might be one of the prophylactic options for adult patients with migraine.