I recently had a Prolia shot, was prescribed for significant Osteoporosis. Six days later I began a severe migraine that lasted 5 days. Imitrex shots didn't work, went to the ER, the following day I went to outpatient for more treatment. Nothing helped. I'd rated it the migraine a 10. Please consider other treatments if you need them and research them before hand. They are given every six months, I've had my last one.