This is my first time posting. I'm 51, perimenopausal, spent the last 10 years on/off again with chronic migraines, rotating among preventatives. Abortives don't work on me. Back in Jan, My Dr (Gp) suggested trying B2 400mg daily to my preventative regime. I try to fit Cal/Mag in mid day when I can. I tried taking 50mg 2x a day. I settled on this dosage after reading that you can't absorb more than 37 mg at any one time, urinating the rest out (why "they" choose 400mg especially if another study claimed 25mg seemed just as effective). These all studies claimed a 50% reduction for the migraines based on participants who had 2-4 migraines a month, but was never done on chronic migraines. So is that a real 50% reduction or just a reduction of 2 (lying by stats). Important if you get 15-20 migraine days/month. Instead of reducing the frequency or intensity of my migraines it seemed to make both significantly worse. So I stayed off the B2 for a couple of weeks, and tried again, same thing. I tried a couple of weeks ago with a time release vit b50 complex to see if that would be better, but again the migraines increased in severity and frequency. This time the only real change was that my preventative was different, I had weaned off Gabapentin 3000mg daily to over several months to Topamax 200mg daily. Any one else had experience with Vit B2?