The case is simple:
I suffer from severe migraine since I'm 4-5yo, and I've only been diagnosed of severe idiopathic osteoporosis a couple months ago. I'm 28 yo. I also broke almost each bone I have between 5-12x, with some notable exceptions. I never broke my ribs nor my back. I started to break my bones while my migraines were starting to get out of control (7-9yo) and I never worried about anything but the migraines, the nausea, and since I'm 16-18yo extremely severe abdominal pain every 12-18months. (enough to make me pass out each time, with a ticket for hospital,)
Last April-May, I had a severe migraine crisis that came a little too soon after an abdominal crisis (end of february). I hired a new physician and I changed neurologist. I wanted results, not excuses. And it paid off. I was diagnosed right on one thing. End of June I started Flunarizine (CCB) and carried on with low doses of Topiramate (2x25mg aday), and I started to take Magnesium as well with a lot of vitamin D.
My Migraine disappeared for 8-10 weeks!
That's what allowed me to realise how serious the osteoporosis was.
Mid-July I stopped the Topiramate (due to adverse side effects I was expecting. I used to take this drug before on very high dosage. I was brain-dead. ). I did a bisphosphonate perfusion at hospital. After recovering from the side effects (flu-like) I noticed that the migraine didn't come back despite the fact I stopped topiramate. Flunarizine + Magnesium + Calcium and Vitamin D was working well enough in combinaison.
I started to gain weigh, and blamed the Flunarizine, and I asked to be switched to Verapamil. My idea. Many studies agree with me, that this was a defendable position.nI spent 6 years at University and I can always find extremely well done studies that agree with me. Verapamil in fact didn't work as well as Flunarizine. Medicine is neither mathematics not law and economics. But I now try to understand why Magnesium + Flnuarizine work this well. For me it felt normal to break bones 4-7x times a year, but that's because I started to break my bones while I was still a young child. To summarise:
Magnesium = Physiologic calcium blocker
Flunarizine = Calcium Channel Blocker. Calcium Channel Blockers don't cause nor aggravate osteoporosis. They work on calcium channel and not against the calcium needed by the bones.
1) Can the cause of an idiopathic osteoporosis be a severe lack in magnesium when someone is 13-18?
a) I always ate plenty of cheeses and drink plenty of milk. I grown up in Switzerland and France. My diet contained a lot more calcium than it ever contained magnesium.
b) Lack of a magnesium. ==> This would explain the very severe migraines I suffered of.
c) I don't know how this can explain the rare but persistent extreme abdominal pain with extreme nausea.
d) I never did glucocorticoids, and went through every migraine treatments starting with flunarizine (7yo) ending with botox injections. I did take some tramadol when I was 10-11, 18, 20, 22, 25, 27, mostly to fight the abdominal pain during 7-10 days, and never again against migraine like when I was 10-11.
e) I did severely abused of only type of drugs: the sumatriptans in all forms. (injections, pills, inhalers)
f) I went to hospital many many time to stop taking sumatriptans under medical supervision. But medication-induced migraine doesn't seem to be a side-effect I cannot recover from. It's easy to know when it starts and when it ends.
e) A couple years ago my blood test results pointed out an adrenal deficiency, but a worst condition was ruled out by two synacthen tests done at a 1y interval.
My specialists are on the opinion that its impossible to develop a severe osteoporosis as a result of an early exposure to morphine, tramadol, depakine, topamax. I'm on the opinion that I started breaking my bones many years before I was given any of these drugs. I'm a lucky guy there must be only one cause to all my health issues, including the migraines. I know I must be touching it right now, but I can't exactly see how and why?