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New Treatment Experiences Part Two: No Happy Ending Yet

Migraine treatments are getting a lot of attention lately. With new options on the market, people in the migraine community have expressed feelings of hope and hesitation. On’s Facebook page, we reposted Holly Baddour’s piece, “CGRPs and Migraine: Navigating Wellness for the First Time in Years.” Her article sparked so many reactions. In a separate Facebook post, we also asked the community if you had talked to your doctor about trying new migraine treatments.

In part 1 of this 3 part series, we shared comments from migraine community members who spoke out about how these new treatment options have been life-changing. Unfortunately, there is no one size fits all when it comes to migraine treatment and some of you have not found relief from trying these new treatments. Here are some comments from those who have yet to find their happy ending.

“The shots are quite painful.”

One downside is the pain of the injections. A few members have mentioned that the injections are uncomfortable and leave a pain that lasts a few days.

“My only issue is that I’m now getting a lump and bruising at the injection site that lasts for days.”

“I recommend icing the injection site for 15 minutes prior to the injection.”

“I wish I had known more before agreeing to the injections.”

Several of you had side effects that made these new medications not worth it. For some, you experienced an increase of migraine attacks after starting this new drug. For others of you, these new medications are causing complications with medications you’re currently taking for other conditions.

“I wish I had known more before agreeing to the injections. By the time I drove home from his office, I had to bury my eyes under a weighted pillow. That is where I spent most of the next five days.”

“I would have preferred no effect. Before CGRP (brand name), I had 14 migraines a month. After two months of CGRP (brand name), now I have 25+ a month.”

“These meds increased fibromyalgia symptoms without positive effects on migraine.”

“CGRP (brand name) caused bad constipation.”

Constipation was a concern brought up by several who tried two of the CGRP brands. Unfortunately, because these drugs are so new, some of the side effects, such as constipation, are only now becoming widely known. That is the risk of trying something new to the market.

“CGRP (brand name) was a miracle drug until I had to go to the bathroom. Seriously, nothing worked. My whole system was so stopped that bending over would cause food to come up. The pain relief was a miracle but the constipation was close to deadly. Took more than a year to recover, still not quite right.”

“My fourth CGRP (brand name) injection is in the fridge but I am done. It hasn’t helped and it caused bad constipation.”

“Medicines that blocked these proteins in mice led to kidney failure.”

Some of the additional side effects may not present themselves until more time has passed and the medicine has built up in people’s systems. One such concern mentioned by a couple of you is potential kidney failure, which happened among mice that were given similar medicines.

“Are patients on the CGRP medications regularly monitored for renal function? Were the participants in the study tested for GFR, creatinine, albumin, metabolic acidosis? When I tried to research this aspect of a CGRP (brand name), it was proprietary. Is the info available now? Medicines that blocked these proteins in mice led to kidney failure.”

“I tried CGRP for three months without success.”

More than a few of you shared that you were able to try the medicine, but didn’t notice any change. You didn’t feel any better or any worse. You then wondered if maybe the drug required more time to have an effect on your body. Granted, everyone’s body will respond differently, so that’s a tough question to answer. But it seems that the majority who did try the drug and had a positive effect noticed its efficacy shortly after starting its course.

“I tried CGRP (brand name) for three months without success. Was that enough time for the drug to work? Will a higher dose improve the results?”

“I have done CGRP (brand name) for three months. The doctor said is it helping. Honestly, I didn’t think so.”

“I tried CGRP (brand name) first, and thought I found a miracle drug. Unfortunately, it only lasted from October to March with no pain. After that the migraines started creeping back in, and then by July, I had to go ER after nine days of a severe migraine.”

“Unfortunately I cannot relate… no effect after five months…”


Hear more from the community

We want to say thank you to everyone who participated in this conversation. By opening up and talking about these new medicines, we are all helping the community make better-informed decisions moving forward. Thank you.

For more comments from the community, check out the original Facebook posts here and here.

Please stay tuned over the next few weeks for part 3 of this New Treatment Experiences series and feel free to share your own story!

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.


  • icorvidae
    6 days ago

    I’ve been on Aimovig 140mg for just under a year and a half and have had excellent results. It first cut my migraine days in half (was getting about 15 per month when I started). Now and for the last few months basically get NO MIGRAINES! I’ll feel that little tell tale gnawing pain behind my left eye and immediately take ginger (1.5g), a cup of coffee and if that doesn’t do it after about 30 mins will take two advil and an aspirin.

    Yes, the shot “hurts”, but nothing to be upset about it, it also only lasts about 3 seconds. I will massage the spot for a few seconds (to avoid the bump) and then ice for 15 minutes. Very occassionally I will get a bruise and some months I might have a day of constipation, but not so bad that I don’t poop. No other side effects that I can associate with the Aimovig. It is a MIRACLE drug.

    I’d recommend ignoring your hesitations and trying it, you don’t have to take it forever if it doesn’t work out. My life has changed so much.

  • Alicia
    7 days ago

    I’ve been on Emgality for over 1 year. I had terrible insomnia the first few weeks, months, but eventually that subsided. I get terrible hives on or around the injections sites and take an antihistamine (when I remember) to help. But the payoff – 20 migraines down to 5-10 a month – is worth it.

    I had a bit of a set back last month – I was 8 days late with my injections, and am working to get back on schedule.

  • Porschesmom
    7 days ago

    I had the loading dose but decided not to continue with the monthly injection of Emgality. At the time of the loading dose, El Lilly’s reps were in the office and I felt a little bit of pressure to try Emglity. I didn’t continue with it because the headache specialist said there was no long-term safety data on any of the 3 new drugs. That bothered me. Also, I never was convinced that I had migraine and it turns out migraine probably fizzled out about 15 years ago and what developed was cervicogenic headache. The triptans that I was still taking had side effects that were mimicking postdrome symptoms and depression.

    Cervicogenic headache, for me, was much easier to treat. I wonder how many people do not have migraine (headache specialist dismissed my questions about other types of headaches and said “it’s all migraine.”). I’m in a FB group for cervicogenic headache and many members have been prescribed one of the three injectables, despite there not being any evidence that excess CGRP is present with CH. I know it’s impossible to research new medications without thousands of “guinea pigs” but there needs to be informed consent, as another poster has eloquently outlined in the comments here.

  • josephinestar
    7 days ago

    I have tried one brand and found no relief.. i am about to embark, today on testing another one. Not sure if there is actually much difference although my Neuro seems to think there is and it is worth it. I found there were no real side effects to the first Aimovig, and hopefully there won’t be any to the second Ajovy, as I already battle leg cramps etc and don’t need to add to that . fingers crossed. Not sure how I feel about being a guinea pig

  • Anne
    7 days ago

    For anyone who tried Aimovig when it first came out, the recommended dosage has been doubled. It didn’t work for me at 70 ml but it did at 140 ml (the new dose). It’s helped to break the pattern of being exhausted from going to migraine to migraine. For me, the benefits outweigh the risks – I want to calm down the nerve pathway that fires giving me a migraine – the more it fires, the more easily it’s triggered to fire. I also make sure i’m getting enough sleep, eat an low inflammation diet, don’t drink alcohol, etc. but it’s not enough. I am more concerned about the increased state of inflammation in my body by continuous migraine attacks – as inflammation is linked to a host of health problems – than by taking medication. At least I don’t have to suffer through work with a migraine constantly.

  • josephinestar
    7 days ago

    Hi Anne, Aimovig didn’t work for me but glad it did for … I also follow along similar lifestyle like yourself but am interested in what makes up your low inflamation diet…I have back, leg and hip issues along with the migraine and would love to help that… I follow what is probably best described as a dirty keto eating program so what sort of things do you eliminate if you don’t mind sharing.

  • Holly H.
    7 days ago

    Medicines and I just don’t get along, as I over-react, have untenable side-effects, or big-time opposite reactions. So, the only thing I have right now is oxygen therapy 3 times a day for the clusters (somewhat eases them back); nothing for the chronic/constant migraine, unless you count 1 Tylenol. Although not a help for migraine pain and systemic effects, I do get some decrease in the speed and intensity of the visuals in the 24/7 migraine aura with the O2, which seems to have been an unexpected benefit.
    RE Aimovig – It started to help, then I started going into a paralyzed-like state to all the way passing out; no warning, no pattern to them. RE Emgality – I got erythema multiforme with very sore skin and enlarged/tender glands quite quickly.

  • Ruth
    7 days ago

    After 15+ years with chronic migraines, I once again went to my neurologist for migraine and pain from spinal stenosis. She spent about 1 minute with me and gave me the application for the new CGRP miracle drug. When I got it I read every word of the package insert, got my husband to read the results of the clinical trials, look at the charts and graphs, and the results. I also enlisted a friend who is a medical professional to look at it as well. The reason was that the “results” were not at all matching up with the marketing on the package. In fact, the results were not impressive at all. Not only that, the side effects had not been well investigated. Of course there’s going to be pain at the injection site. And what drug doesn’t cause constipation–unless it causes the opposite, or both? There was no reporting on liver toxicity, nothing on cancer, etc. So basically the company was using the general population as another test group. The outcome looked so highly improbable or inconsequential, I stuck the package in the refrigerator and 10 months later, that is where it remains.

    Now here is the amazing part: I have had about 4 migraines in the last 10 months. Before that, I was having about 8 or so per month. That is what is called a “coincidence”! You know, a happy one, and I’m grateful for it. But it is also what researchers are supposed to screen out. I’m guessing they don’t. So I got the drug, did NOT use it, and since putting it in the refrigerator have seen my migraines go to nearly zero. For over 15 years I had them nearly every day. They started when I was 45 and I am now 64.

    I have studied probability and statistics as an undergraduate and at the graduate level, and I know how to do a study, how to collect data, choose samples, report errors, and analyze data. And I know when a marketing company is trying to manipulate me. I just wish more doctors would be more aware.

    I think if you want to try an experimental drug, you should have that option. But you should know that it is experimental and be told in plain English what the package insert, the data, the studies say and, more importantly, they do not say. Migraineurs should not prey for big pharma.

  • Porschesmom
    7 days ago

    I totally agree with you. I’m in a FB group for cervicogenic headache and posters are stating that they are being prescribed these new migraine drugs. I haven’t been able to find any data stating these therapies are appropriate for CH.

  • Marcus
    7 days ago

    I just wanted to shout out a big THANK YOU to all of you at and Health Union. What you do is a tremendous service to us who live with all the differing forms of this crazy disease.
    Specifically, to our ‘Editorial Team,’ thank you for addressing all of the differing experiences people are having with the new CGRPs. And for always being so affirming of ALL experiences–whether some are having a brand new chapter in their life with migraines (I’m thrilled for each of you; I truly am); while others are getting no benefit at all (I’m so, so sorry it didn’t pan out for you); and still others are having side effects which are so varied, including some not at all anticipated (that’s when meds can be so frustrating; thank you for bravely sharing your experience so others of us can benefit from such knowledge).

    Again, thank you for being here, and serving our community with candor and compassion. I honestly pray that somehow all that you are giving to others of us will return to you tenfold–indeed a hundredfold would not be too much at all.

  • Marina
    7 days ago

    My, my my. I am not surprised. When this drug came out, I quickly researched how it would work in my body and messing with the proteins in my body was a big red flag to avoid this drug. I also looked in the vast side effects which were too profound for me to even consider using it. My kidneys and liver are very precious to me as my brain’s proteins. Just because the FDA allows a drug to be distributed does not mean it is wholly safe for all and they have no idea of long-term effects on the users.

    I took the Imitrex shots for 19 years. They were a miracle drug for me, (and the shot did not hurt one bit,) but they destroyed my veins in my legs. I chose to stop using them and truly focused on watching every SINGLE thing I put in my mouth. I monitored the combinations of foods. I made sure I knew the barometric pressure of the next day’s weather. I limited all preservatives, soy, and fermented foods, (which also means I am thin). I eat out at only a couple of restaurants and make all my food. This has resulted in limiting my migraine attacks. I limit my time with people who cause me stress because stress can trigger migraines too.

    I think it is the responsibility of every migraine sufferer to try and find the most natural way to limit the headaches. I know that not all will be avoided, but I have lived with migraines for over 40 years and doing without many things is a trade off I have accepted to not lose days upon days of being nauseated, in pain, wearing dark glasses and lying in bed with ice on my head.

    CGRP’s is not the way to go. I considered them too dangerous and not worth the horrible side effects. Everything we put in our bodies, from food to drugs affect it. I was not going down that road. To be fair I take a pain killer when I have the migraines that I can not stop, but I have learned to abort many, many of the migraines as they are beginning. That is the key. Trying to stop them before they start and I was so determined and had will power of steel to do it because I know the pain and the loss of time over the years that I will never, ever get back. There is a better way than these drugs that the pharmeceutal companies are toting.

  • HollieCrtr
    7 days ago

    The shots have worked well for me. I was on them for 3 months without a harsh migraine. Maybe a slight headache here or there. My insurance was giving me a hard time about covering it so I missed a dose and 2 weeks later had a 4 day migraine. I am concerned about the side effects though. I have yet to experience any, but the possible kidney failure worries me.

  • ninafranco
    2 months ago

    I am almost SHOCKED to read that some people have felt pain with the injections. Where are you injecting yourself? Have you tried an alternate site? I have been using Aimovig for about 6 months, two injections a month, that would be 12 injections and I barely/do not feel them. I sort of flatten the skin in the top back- side of my thigh, a little bit back and below of my hip bone and push the button. Since I do two injections I do the same on both legs. Sometimes I feel a tiny pinch, sometimes I feel nothing and I double check the injector to make sure it actually worked. I am a 66 year old woman, not some tough guy, so I can’t help but wonder why the injection would hurt others. My suggestion would be to ask your doctor to do an injection ON you and see if that one hurts. I was nervous the first time I used Aimovig so I asked my neurologist to administer the first one to make sure I knew exactly how to do the injection. Good luck.

  • waffles
    1 month ago

    I had pain with Aimovig injections but not Ajovy, although the Ajovy made me pass out for several minutes. Neither helped though, not a single bit. And I know how to give myself shots as I have other injectable medications that have never pained me. I usually don’t even feel those, except a slight pressure from the volume. Even that fades in a few minutes. Even when a friend who is trained to give shots for her job did it, it still hurt.

    Sometimes things hurt when they shouldn’t and it doesn’t make any sense. It doesn’t mean that they did anything wrong. I showed my doctor with the trainer pen they had in the office and she said I did it right.

  • Peggy Artman moderator
    1 month ago

    @waffles, I’m sorry to hear you had such a bad experience with injecting the CRGP medications. It sounds like you administered the injection properly. You are not alone in your experience with these types of medications not working. I wish you the best in finding something else that reduces your pain.
    ~ Peggy (

  • ninafranco
    2 months ago

    Update. Again, I was shocked to see that some people have trouble with the shots so I decided to pay attention when I injected myself. Today I received my injections. They were in a box with ice packs. I removed the box of injections and left the box of injections on the counter until they warmed up. My doctor told me NOT to inject myself with cold drugs. Could that be a problem? I previously read that the injections can be left at room temp for several days, but I never have left them more than a couple of hours. Several hours hours later I took off my pants, sat down and injected myself in the upper thigh as I said before, one in each thigh. The first injection stung a tiny bit, no worse than maybe a snap with a small rubber band, the second was almost imperceptible. As I said, if your injection hurts more than this maybe consult your physician, you might be doing wrong.

  • ninafranco
    2 months ago

    P.S. I have had no bad reactions to Aimovig. I feel the same generally, neither more nor less tired, or achy in the days before and after Aimovig. My insurance would not cover it so I am so grateful that the company is paying. I still get TINY migrainous headaches, but nothing I can’t handle with OTC meds. I have not had a major migraine since starting Aimovig–fingers crossed.

  • Marcus
    7 days ago

    Ninafranco, I’m glad to hear that you’ve had a great experience with Aimovig. And that the injections don’t hurt. You, that is. I’m glad they do not hurt you when you inject yourself. Awesome!!

    At the same time, please, please, I beg of you to have compassion on those who experience something different. Just because they experience horrendous pain with the shots DOES NOT mean they are doing something wrong!! Please be considerate of others who ARE SUFFERING from the shots, or who are experiencing no help from the medication.

    These are brand new medications, and few realize how few humans actually go through the process of being tested in the process of having these medications approved for the general population. We have what I consider to be a very good system in this country to test medications before approval, but it is still a very small sliver of the overall population. Once they are rolled out, now all of a sudden the “sample testing group” is expanded exponentially. And things are uncovered that maybe were not determined beforehand. Which is why sites such as are so important, so lots of us can exchange our experiences. For which I’m so thankful.

    And again, I’m thrilled how well Aimovig is helping you. I’ve had migraines since infancy, and for the last 25.5 years New Daily Chronic Migraines, which for the last 10 yrs have become Intractable or Refractory. So I’m joyous for you. I truly am. And best wishes.

  • April.Sluder moderator
    2 months ago

    Thanks for sharing your experience @ninafranco. April – Team

  • Casper6
    2 months ago

    I have heard good and bad about the aimovig. With the co pay card and my doctor suggestion I try it, I did. I wish I never would of. With in 12 hours I broke out in hives. I have never had them like this before. They were all over my body. Was put on predizone. But that was not all, I had stomach pain and gas pressure in my chest around my heart. It would go way with heat and antacids. I also felt like my migraines increased. The rash went away with in a few days with the medication. But the other side effects lasted longer and am still having issues with gas pressure. I did not have this problem before I did the injection. For those it helps I am happy for you. But I am not willing to try any other CGRP type injections. I’ll stay where I’m at. Best wishes to all!

  • BrownT
    2 months ago

    Thanks for discussing some of the negative side effects. It seems the company does not want to hear from patients that have side effects. I took Aimovig for 8 months before I gave up on it. I keep hoping that more time would improve the migraines. I was willing to put up with the negative side effects. I found Aimovig helped a little with the pain but severely increased all the other aspects of migraines. I was constantly nauseous, had vertigo, light sensitivity was unmanageable, sounds and odours were overwhelming. I could not function. I never experience all the other aspects of migraine so strongly before. It really helped me understand just how debilitating all aspects of migraine can be.
    Since I have stopped the medication everything settled down again, thank goodness. The company has never touched base to find out why I opted out of their program. I am hopeful that maybe one of the other CGRP may work better if they ever come to Canada. At the same time, I am nervous that the side effects will be overwhelming again.
    I have never heard of a drug or series of drugs that have ignored the negative side effects before. Usually companies want to warn about everything so they will not be liable.
    Thanks everyone.

  • newbattleaxe
    2 months ago

    I spent eight worthless months on Aimovig. The injections weren’t so bad, but that’s the only good thing I can say about the drug. I spent 8 months in a brain fog, with increasing vertigo and several bad falls. One fall led to a concussion & 3 knocked-out crowns. I had two trips to the ER during this time, one for what I thought was the mother of all migraines – sinusitis. The other was for an impacted colon. I had absolutely no change in migraine frequency or severity.
    In my fourth month of Ajovy, I’m seeing up to SIX days in a row migraine-free! I haven’t had such freedom in years! These injections hurt more, but to be able to make plans, and be alert & feel safe to drive are worth it all.

  • MelanieM moderator
    2 months ago

    newbattleaxe, I am so sorry to hear you had such a bad experience with Aimovig- but I am glad to hear that Ajovy is making such a difference for you, that is fantastic! Thanks for sharing with us. ~Melanie Merritt ( team member)

  • Msmmain
    2 months ago

    I had a terrible response to both Aimovig and Emgality. The Aimovig caused my migraines to get worse in severity (I was already having 30+ migraines/month) and less than 72 hrs after the 2nd shot I had to go to the ER for an intestinal blockage that started almost immediately after food left my stomach, which the internal medicine specialist had never seen before. My Neurologist switched me to Emgality and I ended up eating next to nothing for nearly 45 days due to how severe the abdominal cramping and vomiting became from it. NEITHER helped my headaches, and ever since then (I stopped taking both in May) I’ve had consistently MUCH worse migraine pain and nausea, and my Doc doesnt know if it’ll ever go back to my old “normal”. I wish I had never heard of these drugs!

  • MelanieM moderator
    2 months ago

    Msmmain, I am so sorry to hear how terrible your experience was. I hope that you do see a reduction in your migraine pain and nausea- it sounds like you have been through quite a lot. I hope you have a gentle evening. ~Melanie Merritt ( team member)

  • MaddieG
    2 months ago

    I had really good luck with Aimovig but my insurance won’t cover it now that the year of copay/insurance assistance is up. So they switched me to Emgality which was a regular syringe the first dose I got and I passed out before I could take it. 2nd dose came and I took it. Now I’m fighting with the insurance because they won’t let me get it filled at the local pharmacy so it has to be mail ordered which is difficult because of the refrigeration. In the last 7 months I’ve had one dose and am pretty much in constant pain. I went a week without a migraine on the Aimovig but now… I’m back to where I started. It’s so frustrating because one would think I should be able to take the medication that worked for me.

  • MelanieM moderator
    2 months ago

    MaddieG, I hear your frustration! First and foremost, I wanted to let you know I am prescribed Emgality and it comes in an autoinjector similar to the autoinjector that Aimovig has. I had to switch from Aimovig to Emgality for insurance reasons also (which honestly I don’t understand, because Aimovig sent me something in the mail to renew the assistance program for another year and I filled it out and was approved). But it does appear that Emgality must come in two versions, I wonder if you could request an autoinjector? ~Melanie Merritt ( team member)

  • olivetodd
    2 months ago

    Thank you for this article. I have been reading the newsletter for the past few years and just suffering silently, with about 15-18 migraines/month. Five years ago, I had to quite my job, because I had a 40 day migraine, and going into an office with computers and fluorescent lighting every day was just not possible. I have been on many daily medications, to no effect, and Botox made pain 10% better for about two years. But mostly nothing helped. Until I was given Sumatriptan injections about 4 years ago. And part of my life was given back to me. However, after all I have read, it seems as if taking these injections 15-18 times/month might not be a great idea for my cardiovascular system. But it’s the only thing that has even remotely helped. When I started reading about the CGRP’s, I contacted my neurologist and started on AIMOVIG back in July (the needle is no more painful than the Sumatriptan injections I have been taking every other day). Now, I am experiencing migraines about 5-7 times/month. Which is a miracle. I have so many of my mornings back, which is incredible. I wonder how long this will last? Yes, there is constipation…but I counter that by taking magnesium citrate, which totally helps. I look forward to hearing more about the CGRP’s and other potential future pain/disease management. Sending good thoughts to all of you out there dealing with this disease! You are so not alone.

  • MelanieM moderator
    2 months ago

    olivetodd, I am so glad to hear that both Sumatriptan and Aimovig have made such a difference for you, that is wonderful. Thanks for sharing your hope with us! ~Melanie Merritt ( team member)

  • RoseDM
    2 months ago

    I started on Emgality a year ago. It cleared my head for the 1st time in over a dozen years. I still get occasional migraines and occasional headaches but at an 80% reduction than before. The shots are very painful (lingering pain for 30 minutes) and initially I had swelling for up to 4 days. Now I take an allergy pill & an anti-inflammatory (Aleve) 10 minutes prior and ice the area before the injection. No swelling or redness and no lingering pain. While the initial injection is still very painful, it diminishes in about 20 seconds. For me, it is so much better than the contant headaches/migraines that I lived with before.

  • MelanieM moderator
    2 months ago

    RoseDM, I am so glad Emgality is helping you so much- and thanks for sharing that you have been helped by icing before the injection (I have found that to be helpful as well), and the allergy and anti inflammatory. I am glad that you have a routine that is helping you! ~Melanie Merritt ( team member)

  • Ellen H
    3 months ago

    Thank you for publishing this list of the miserable side of Ajovy, etc. It is my understanding that TEVA Pharmaceuticals never followed up on the patients who dropped out of the clinical trials. If so, no wonder the drug reps are telling doctors who tell patients that there are no side effects. My doctor said he has 400 patients on Ajovy and I am the only one who experienced the miserable adverse effects. He actually said, “Your body cannot handle medications. I am sorry I asked you to try it.” Thinking of his apology, I am very touched by his words. Where will I go when he retires?

  • Lawrence moderator
    3 months ago

    Hi Ellen! You are most welcome, thank you for your response! We are happy that you found meaning with this article. It sounds as though you and your doctor have a strong relationship. In thinking about his future retirement, I can imagine that this is a scary thought for you! You are right to consider what you will do when that time comes. Finding a new migraine doctor that understands your needs and symptoms is a long process!

    I am sharing with you a link to a recent article from earlier this year that touches on handling your doctor’s retirement: We would love to learn more about your thoughts, and I feel that many of our community members can benefit from your advice and input on how you found your current doctor!

    Wishing you a pain-free day! -Lawrence ( Team)

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