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CGRPs (calcitonin-gene-related peptide)

Have you experienced side effects from Emgality?

  • By MadWithMigraines

    I already posted this as a response to someone else who asked about weight gain, but I’ll repost here in case anyone checks.

    So I’m at the end of my 2nd month and where I’ve had less headache “ache” severity (didn’t seem to do anything about the non-ache symptoms which are still terrible) and fewer headache days during my pre-menstrual attacks I also:

    gained 7 to 10 pounds (ongoing), have had 2 irregular-timed and heavier bleed menstrual cycles, and have a sluggish GI with mild to moderate constipation.

    I’m currently debating on whether or not to continue because the weight gain was not something I expected and I have a familial history of diabetes along with hormonal issues which I definitely don’t need.

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  • By kmac33

    Emgality has helped my migraines immensely. Unfortunately, it has caused itchy hives all over my body for weeks and weight gain in middle. I want to cry because I was so happy migraines were gone but can’t take the itching!!!

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    • By dawnybear

      OMGoodness, the Itchiness!!! I can’t take it. And I gained 20lbs in like 2 weeks. didn’t do much for my migraines. I see my neurologist in October. I stopped Aimovig because I thought it might have caused my hair loss. I’m not sure now. It might have been my Occipital Nerve shots. I just don’t know. Because the hair loss is just in that area. And I’m on Minoxidil and it only sheds a little when I get the shots now. I may go back to Aimovig. I just don’t know. This is so frustrating.

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  • By Peggy Artman Moderator

    I have been taking Emgality for the past 6 months and I wasn’t having much improvement until this month. I’m more sensitive to what my triggers are. I am more active and am going out more.

    My weight has been very stable for most of my life, but lately, I have gained a few pounds. I couldn’t figure out why until others reported weight gain. I am willing to stay on Emgality for a year because I seem to be a slow responder to this kind of medication. Depending on how much weight I gain I will have to look at benefit vs. side effects.

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  • By Peggy Artman Moderator

    I have tried other medications where the side effects go away as my body adjusts. Hopefully, it will be that way now.

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  • By Willowpond22

    I have had 7 monthly injections, following the loading dosage. At this point I will not be continuing this medication. For me, the side effects are too negative for me to continue.
    – the good news is that I went from 8 migraine days/month to 2.

    Unfortunately, the side effects include:
    – weight gain of 7-10% of body weight
    – swelling of legs/feet
    – fatigue
    – feeling of difficulty breathing (cant catch a good deep breath)
    – anxiety/emotional distress

    I’ve been the same weight for 24 years & NEVER gain even one pound. Since the weight gain I actually also increased my running & cardio 3x what I had been doing…
    Just skipped my 7/1 dose & hoping that the symptoms fade & the weight comes off as the half-life starts to burn out.

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  • By Peggy Artman Moderator

    @willowpond22, at my last appointment with my neurologist, I mentioned some possible side effects of Emgality and my doctor told me the manufacturer wants to know about all side effects. They took note of them and I’m assuming they will report them. I suggest you tell your doctor about all side effects you notice in case they are reporting them too.
    ~ Peggy

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  • By TwillaMassie

    I started Emgality in February. At first, it was great and it reduced my migraines from to weekly to monthly. Now the severity /pain of the migraine has reduced but the frequency has increased. I am back to weekly migraines, weight gain, increased dizziness, nausea and sensitivity to light/sound. I also get the chills a lot. I am normally very warm and keep the fan on and thermostat low etc.
    I am very sensitive to medications so I am not sure if I will continue the Emgality or not. I am waiting on a consult with a neurologist.
    I am missing a lot of work and life events. It is incredibly frustrating. I am glad to have found this forum and others with similar experiences.

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    • By Peggy Artman Moderator

      TwillaMassie,
      Welcome to our community! Your experience sounds very frustrating. You are doing the right thing by consulting your doctor about this. I hope you can find another treatment that works for you. Keep us posted.
      ~ Peggy

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  • By Frank McFadden

    I am just now starting with emgailty and my neuroligist is continuing with Trokendi XR 100mg daily as well. The Trokendi has been working well – migraines reduced by more than half – some weird side effect for a few months but they are gone now. I’ve taken only 3 relpax in the last month. Anyone else here on both Trokendi XR and Emgality? Kinda expensive for us medicare folks but if It works, it’s worth it.

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  • By Peggy Artman Moderator

    mortician510,
    Welcome to our community forum. Thank you for sharing your experience with these treatments. It’s great that your migraine attacks have been reduced so much. I hope this continues. ~ Peggy

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  • By JamieK

    After one dose of Emgality, my entire body hurt, especially around my rib cage. I had itchiness everywhere and gained weight quickly. I have not taken any more, and after bad side effects with Aimovig also, am leery of trying the newest one.

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    • By Peggy Artman Moderator

      JamieK,
      It sounds like your body didn’t like Emgality. I have heard that rashes are common with this medication. I can understand why you are so cautious about trying either of the two other CGRP’s.
      Peggy (Migraine.com Team)

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  • By MissyP

    Hey everyone. I started Emgality just one week ago. Since taking the loading dose I have had significant dizziness (to the point of almost falling over), nausea, weight gain around midsection, vertigo, hunger, bouts of crying spells (I am not a crier), increased achiness in joints and ribs, significant brain fog, chills when I’m usually hot, and now increased anxiety, almost to the point of a panic attack. Oh, and I have been wheezing ever since taking the med. I do have asthma but felt fine prior. On the positive side, the migraines have been reduced significantly. I guess it’s a matter of what you want to put up with. 🙁

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  • By MsStaciNicole

    I received my loading dose of Emgality September 11 (one month ago) and went from migraines 3-6 Days/week to ZERO migraines since that day.

    Did I experience constipation? Yes. I knew this could happen and I went from IBS loose stools to very hard rocks in about two days. I cleaned myself out the next day and then started a nightly dose of Miralax for the next two weeks to get back to normal. After that time, i have not needed Miralax to keep me going.

    I injected my dose today and will see if I will need to go back to the nightly Miralax dose for these next couple weeks.

    Overall, this drug has been the biggest game changer, and I say this having tried every preventative drug possible and having Occipital Nerve Decompression surgery last July.

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  • By MBrunson78

    I started Emgality injections in November 2018…my mother passed away December 1, 2018. Through all of the grief over the coming months, I had not ONE migraine. None. This after 30+ years of chronic migraine and having failed all other prophylactic medications. However, I started experiencing very negative side effects that I chalked up to grief- depression, anxiety, panic attacks all day long, and weight gain (20 lbs!). Seven months later, and the panic attacks were increasing as was the anxiety (aggression and the fight or flight feeling)- this just was not sustainable, nor was it due to grief alone. I finally looked up user reviews on Drugs.com and found pages and pages of people complaining about the same negative, supposedly never reported to Eli Lily side effects. I stopped taking the injections in June 2019- it takes over 5 months for the medication to completely leave your system. It is now November 1st and I can finally take a gentle sigh of relief- the depression, anxiety, and panic attacks that had become my daily life are GONE. But the migraines are back. It is so very frustrating to finally find one preventative treatment that actually worked 100% but the trade off was equally debilitating side effects.

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  • By Graham211

    I began taking Emgality in February 2019. I have suffered from migraines since I was five y/o. During my pregnancy with my daughter in 2011 my migraines were at an all time high; more than 20 migraine days a month. Emgality has brought that number down to three. Not only do I have three migraine days, but they are totally manageable. The only downside has been the weight gain. 26lbs. I assumed it was a side effect, but now am wondering if it’s because I am no longer throwing up half the month. I am making changes to my diet in hopes that will help. I’ll update if I see any changes.

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    • By MsStaciNicole

      Update: I’m on my third injection of Emgality. I have not had any side effects after that initial round of constipation. I have not had one single migraine since my first injection September 11, 2019, and I was having them 6 days/week. I haven’t noticed weight gain so far, but I will keep an eye out.

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    • By Peggy Artman Moderator

      @msstacinicole, sorry for our late reply. It is awesome how well you are doing on Emgality. No side effects and fewer migraine attacks. Sounds great to me!!
      ~ Peggy (Migraine.com team)

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    • By Peggy Artman Moderator

      @graham211,
      I am so happy to hear of your success with Emgality. Some of our readers have also reported weight gain. You can report side effects of Emgality to Lilly if it is really bothering you. Wishing you a low pain day.
      ~ Peggy

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  • By Loulou

    I tried Aimovig a year ago, and I am trying Emgality now. This is the second month and the migraines are much worst. Horrible. Can we find any documentation on patients like me that the medication increase the migraines. I would appreciate to read some littérature about those bad sides effects on some patients. Thank you all.

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  • By Ilex

    I am very glad I saw this thread, I had chalked up weight gain to other factors, but now I see that it could be the Emgality.

    I have seen improvements in headache/migraine, but feel like I have fallen off a depressive cliff. Very sudden, very extreme symptoms of depression.

    And this is a weird one, but I feel like I have lost a lot of my sense of taste. Googling I found this study of mice where they did lose sense of taste from CGRP drugs: https://www.ncbi.nlm.nih.gov/pubmed/26377461 But I haven’t heard anyone else report that, so eh.

    I have only been on Emgality for a month and a half, I have used substantially less Aleve and Frova to treat migraines since starting, so it is doing something. But I really don’t know if the side effects, especially the depression, are worth the trade off. I am going to slog through another month and see if the side effects ease up at all.

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    • By Peggy Artman Moderator

      @llex,
      Thanks for your input about Emgality. We have had a mix of responses from our readers. Its great that Emgality has substantially improved your migraine frequency. I can understand your concerns over side effects. Most of the time doctors recommend trying something new for at least 3 months to see how you will react. Some side effects go away over time.

      About the depression, do you normally experience it in the fall and winte? A lot of us have seasonal affective disorder. But if that is not you, then you should probably discuss this with your doctor. Good luck and keep us posted!
      ~ Peggy (Migraine.com team)

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