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Ajovy Symptoms?

Hi! I was on Aimovig for a year with great results. It reduced the number of migraines I experienced each month with no side effects. So of course, my insurance randomly decided to switch it to a non-formulary drug. I have to try Ajovy and Emgality without success before they will approve Aimovig again.
I gave myself the first injection about a week ago and have been feeling really off. I feel very irritable and have been experiencing an unusual level of insomnia. I know injection site reactions, constipation, and hair loss are some of the reactions commonly experience, but I was wondering if anyone experienced changes in their mood and sleep? My migraines have been terrible so I am debating whether to give myself a second injection anyway.

  1. Hi EmilyM, thank you for reaching out! I hear how awful you have been feeling since switching to Ajovy. There have been a wide range of responses to the CGRP medications from members of the community. I thought this discussion forum about side effects with Ajovy might be of interest to you: Also, if you haven't already, I would encourage you to report your response to the FDA's MedWatch site: Have you discussed your response to Ajovy with your doctor? S/he should be able to advise you best on how to handle your next scheduled dose. Please keep us posted on what you decide and how you are managing. I hope your insurance will approve your return to Aimovig before too long! Wishing you a gentle day. ~Allyson ( team)

    1. I have been on Ajovy for about 2 years. I just recently starting having some vision issues and was diagnosed with a cataract in each eye - and I am only 32 years old! I am starting to wonder if Ajovy could be the culprit. I did a little bit of research on this class of drugs and it sounds like the protein that Ajovy blocks is important in skin and eye health. Anyone else have any vision issues after starting Ajovy?


      1. I am so glad you posted this. My migraine attacks switched drastically in November 2019. The pain I experience is now in my face and my left eye. My vision can be obstructed in that eye really out of nowhere. I drove off the side of the road during an attack.
        I was prescribed Ajovey in January 2020 and took it a year, with no improvement. I did see an eye specialist who did not find anything structurally wrong. However, I believe the eye pain is worse.
        The Neurologist is looking at Trigeminal nerve pain and giving me CGRP IV infusion, which seems to be the newest magic potion being peddled. I have not decided if it is the right decision for me.
        I am sorry for the side effects you experienced and hope you can have your sight fixed.

    2. Hi everyone, I’m new to this group but saw a thread about Ajovy side effects and figured this would be the best place to see if others have had similar experiences. I’ve done 2 months of Ajovy shots along with continuing Botox injections every 12 weeks. Since the first month I’ve had intense and restless itching on my neck, to the point where it was scratched raw and was always red. Nothing would take away the itching. This continued for 2 months and has only started to ease up now that I’m 1 week over due for the 3rd months shot. It was after the second months injection that I noticed a significant increase in anxiety and depression symptoms. This part was really difficult to cope with. I did find that it was helpful somewhat with a reduction in pain days. But the mood side effects are awful. I have an appt with my neurologist tomorrow to discuss. But I’m 95% sure that I’m going to discontinue the Ajovy. Has anyone else has any similar experiences? I’m thinking the neck itching/redness may have been a form of allergic reaction? Thoughts?

      1. Hi @JennG, I wanted to link an article shortly which states " In some people, Ajovy caused a hypersensitivity reaction (severe allergic reaction), which may appear as a rash, itching, or hives. Ajovy should be discontinued if an allergic reaction occurs." The article can be found here: It does seem like this is listed as a primary side effect. Let us know what you think. ~Melanie (team member)

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