Hi erryjdiakiw, thank you for reaching out! I hear how much you have been enduring through the detox process! It can be so rough to get through. We cannot offer medical advice over the internet (for your safety!) but I would encourage you to reach out to your doctor to ask her/his advice about taking tramadol again after being off it for 45 days. S/he will be able to make the best assessment for you. Please keep us posted on how you are managing. Wishing you a gentle evening. ~Allyson (Migraine.com team)