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My Amitriptyline has stopped working

I have had neck and headaches along with vertigo for 8 years. It took 4 years to diagnose as my main symptom was a neck ache. I was eventually diagnosed with vertiginous migraine. Mt migraine used to be 24/7 and I felt like killing myself. after diagnosis and after being on Amitriptyline for 3 days it just went away completely. However 2 weeks ago it came back. I doubled my dose to 37mg from 25mg. I am now unwell with the migraine just as I was 4 years ago. Has anybody else's medication stopped working?
I wonder if I will find another drug that will work

  1. Ugh, I hear how frustrating it is when our medications stop working. You're not alone, we've heard from many who deal with this.

    Please don't lose hope! It can take 90 days, sometimes longer before we notice improvement in our migraine attack symptoms and/or patterns when we start new medications or change the dose. I know this is disheartening especially when we are in pain.

    I think vertiginous migraine may be vestibular migraine and we have information on this here;
    Another wonderful resource is The Dizzy Cook who lives with vestibular migraine;
    I hope this information is beneficial, will you let me know what you think? I'm sending you pain free wishes, Nancy Harris Bonk, Patient Leader/Moderator Team Member

    1. Hi Steve. My heart goes out to you -- it's so scary when medication stops working. This is actually something we hear quite a bit in the community with all kinds of medications. It's very common for our migraine experience to change throughout our lives, and often there's no real reason. Life with migraine involves a lot of trial and error -- your body may be telling you that it's time for something new. Try to stay hopeful as you begin the process of finding what will work best for you now. As Nancy above often shares, there are more than 100 various treatments, pharmaceuticals and otherwise, and it's all about finding the right combo and doses for you.

      Are you happy with your care team? Whenever possible, we encourage our members to work with a board-certified headache specialist. This is different than a general neurologist as they have chosen to focus on headache disorders, as opposed to all kinds of conditions.

      You can find directories of headache specialists at and We don't endorse any particular doctors, I just want to make sure you have access to the most knowledge and expertise.

      We are here for you as you try to figure all this out. You don't have to go through it alone, okay? Please reach out to us anytime, even just to vent or say hi. Sending a hug your way. -Melissa, migraine team

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