I've recently been taking propanolol (Inderal) as prescribed by my Neurologist, but it did not seem to be helping. Then my Naturopath suggests I try 300mg 2x a day of 5-HTP (which increases serotonin in the brain). I have tried 5-HTP before, although it was a much smaller dose with only 100mg 1x a day. I am still taking the propanolol (40 mg 2x a day) and the 5-HTP, and my migraine frequency seems to have reduced. I don't know if it's just one of those less severe times I sometimes go through or if it really could be from the combination of these two medications. I had heard of doctors prescribing both together but only heard that once. Has anyone else ever heard of these being prescribed together?