Me again, writing as worried and upset as last time. I started randomly waking from migraines during summer of 2019. It would be 1x month, a few months and a row. Then the next few months would be ok. Once I started Botox, this stopped during cycles 2 and most of 3. It is happening again and I have had 2 more migraines per month on Botox cycles 3 and 4. I had an amazing result with Botox cycle 2. So confused. No idea how to prevent REM sleep migraines. Please help. These migraines are really life ruiners.