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How to detox from rizatryptan

I think iam getting rebound headaches. The rizatryptan isn't as effective with the increase of my migraines. The migraines are pretty much everyday having to take 3 rizatryptan in a 24 hr daily. I really can't say when it started. It happened so insidiously. Now how do I get off this medication. It's been very painful. I try but then I can't stand the pain any longer and give in and will take the tizatryptan. I tried to take ibuprofin instead but it doesn't do much. I will be seeing my headache doctor this week.

  1. - Thank you so much for sharing this important question. I'm so sorry you are experiencing this uptick in attacks and pain. Rebound headache does happen insidiously, as you said. And it is possible to experience that type of headache from a triptan. I'm so glad you will be meeting with your doctor this week as your primary question (how to detox and pull up from the cycle of a rebound headache) is best asked of your doctor. S/he can assist you in the creation of a plan of action to shift away from taking the triptan into something else until your body makes the transition effectively. All this said, it's also possible that you are in the midst of an intractable migraine attack and require a different type of intervention to assist you in calming the pattern you are in. Either way, your doctor is your next best step.


    Here is some more information on rebound/MOH (medication overuse headache): https://migraine.com/headache-types/medication-overuse-rebound. And: https://migraine.com/forums/how-long-does-it-take-to-recover-from-triptan-overuse. Please don't give yourself a hard time about falling into this pattern- it's very easy to do and it happens to many of us. We are all merely seeking relief from pain, after all.

    Hopefully, ultimately, this can inspire an important discussion with your doctor on the topic of finding an effective preventative for you that will do a better job of keeping you from getting breakthrough attacks in the first place.

    We are absolutely here for you as you continue along this journey. Please let us know if you have additional questions and how your appointment goes. Thinking of you. Warmly - Holly (team member)


    1. Thank you. I guess I thought at first that my migraines were just getting more frequent. But then I read about someone in the forum that they realized they had MOH. So I thought that maybe that's me also. It seems like all the preventive I've been on work for awhile and then lose their effectiveness. I'm sure the next drug will be topamax. I'm already on propanolol, amitryptiline, gabapentin. Thank you for your advise. So grateful for this site!

      1. We hear often about medications losing their efficacy with time. I'm sorry this has happened with you. I've been on Topamax for years - however there are a lot of newer drugs available these days that are designed specifically for migraine prevention (Topamax is an anti-seizure drug that they found helps with migraine). You may want to do some research on a class of drug known as CGRP before your doctor appointment this week to ask if those might be right for you: https://migraine.com/cgrp-new-direction-migraine-treatment or go to this interactive page to explore preventative and rescue options - and see if you find something that piques your interest to talk to your doctor about: https://migraine.com/treatment-options. What day is your appointment this week? I'll be thinking of you- Warmly - Holly (team member)

    2. Hi, is CGRP drugs like nurtec? Unfortunately it didn't work very well. But maybe another one will. My apt is in Thursday Oct 3rd. Thanks for your input, and advice. It is much appreciated!

      1. Hi
        Yes, Nurtec is a CGRP that can be used acutely or preventively. Have you tried any of the other CGRP medications? For some people they are life changing, others not so much.
        Good to hear you'll be seeing your doctor this week. I sure hope your doctor has a new plan for your to reduce your pain! Don't lose hope - there are over 100 medications, supplements, complementary therapies, devices and lifestyle modifications that can be used to manage migraine disease. Most of us are on a combination of these - I sure am! I get Botox every three months and use Cefaly (https://migraine.com/devices) for prevention.
        Rebound (medication overuse headache) is frustrating for sure. Acute medications work wonders for some of us, but best not to take them more than 10 days a month. I'm susceptible to rebound from caffeine, believe it or not. Caffeine is a stimulant, that for a certain subset of us can contribute to rebound headache. I'm OK with one cup of coffee a day, another than that and I'm likely to get into a rebound cycle.
        Please let us know how you make out at the doctor and I'm sending you wishes for a low pain day, Nancy Harris Bonk, Patient Leader/Moderator (team member)

      2. I am so sorry that Nurtec did not really help you. You have tried many things. I saw you mention Topamax may be added next. In the beginning, not exactly for migraines, but, I was on amitriptyline, gabapentin and topiramate together. I started them for neuropathic pain. Then neurology told me that they were changing the dosage as it can help migraines as well. I can attest to medications losing their efficacy. If Topamax is added, I hope it helps you.


        My current CGRP is Aimovig. I have been on it for quite some time, but, it does lessen my migraine severity and frequency. Sending hopes for a little relief for you. Hang in there!! (Tonya, team member).

    3. Hi, Karen! Just checking in on you -- did you go see your specialist? How did it go? I hope you're feeling okay this week and that you can find a solution to your rizatriptan struggle. Sometimes a change is the best thing! Thinking about you. -Melissa, team member

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