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Metoprolol stopped working

Hi all,
I am new to this forum and very happy that I found this place! I have been having migraine for around 18 years now. For the past 17.5 years, I have only been taking Excedrin migraine for the pain but it never worked. I was always miserable, couldn't tolerate the noise, kids screaming, talking on the phone with a loud voice so my old grandma could hear me, etc. Then I decided to take my doctor's advice and start taking metoprolol daily (50 mg at night). It helped and brought the no. of headaches from 7 days a week to 1-2 days. My doctor also prescribed Sumatriptan to take as needed and that was helping for 2-3 months as well. Then stopped working.
I was wondering what medication everyone is on (daily preventive) and what medication your doctor prescribed for taking as needed and what your experience with them is. How often do you get a headache while on these medication, etc.

My headaches are usually on one side, under the left eyebrow where it's close to my nose and most of the time it goes all the way to my temple.

Thank you in advance

  1. Hi @sparkling,

    Welcome to the discussion forum - we're glad you found us!

    I am sorry to hear metoprolol doesn't seem as effective as it once was. It's not uncommon for us to need a dose adjustment or medications change during our migraine disease journey. One of the issues with migraine disease is episodic migraine (14 or fewer attacks a month) can transform into chronic migraine (15 or more attacks a month) fairly quickly if not treated appropriately. I would encourage you to discuss this with your doctor.

    Don't lose hope! There are over 100 medications, supplements, devices and complementary therapies that can be used to treat migraine disease, and more on the way! Let me share this information on migraine prevention with you;

    Let me know how you make out and I hope today is a good day!
    Nancy Harris Bonk, Patient Advocate/Moderator

    1. Hi Melissa,

      I got an email notification last night saying you replied to my comment but when I log in, I am not seeing a new reply from you, so confused.

      Thank you

    2. Hey, sparkling!

      That's definitely strange, because I did reply to you. It's not showing up on this discussion, but I do see it in your user activity log, which you can view here:

      Just in case that doesn't work, I'll paste what I wrote.


      ld moderator replied 18 hours ago
      Hi again, sparkling!

      Thanks for that additional information — Aimovig is a HUGE topic of conversation here on a daily basis! Here’s the basic info page to get you started:

      And here’s a good cross-section of responses to the shots — like I said before, everyone is different, and you could land anywhere on that spectrum. The comments offer more perspectives.

      Lastly, back when it first came out, our advocate Holly was kind enough to make a video showing how the shots work. It’s so helpful to see it in action!

      I hope this helps! Also, for what it’s worth, one of the most common side effects people share here with Topiramate is feeling sluggish and not thinking as clearly. Just something to be aware of. 🙂

      Let me know what you end up deciding — we will support whatever you choose. Hugs, Melissa

  2. Hi Melissa,

    Thanks much for your prompt reply and the helpful info you have provided me. Today I had my appointment with my neurologist and he gave me the Ajovy shot. Is it better than the Aimovig or more popular?

    Thank you

    1. Hi, @sparkling -- sorry it's been a few days. I'm here now! I have no idea if Aimovig is more popular than Ajovy, and even if it were, that doesn't necessarily mean anything because they work differently. It's all about what you find success with!

      Aimovig and Ajovy also work differently. So that's something to consider, too. I am definitely not a scientist, but our advocate Holly wrote an article that puts it into general terms really well. Check it out:

      How are you feeling now? Hope you're doing OK. Take care! -Melissa, team

    2. Hi , thank you very much for your helpful reply. I asked the neurologist who prescribed that shot to see how I should stop metoprolol, he was like stay on it until we see how the shot works. I didn't see the point, to me, if I decide to go that route and take the injection, then I should stop taking the meds! So I started tapering it off, for two nights I took 1/2 pill, then 2 nights 1/4. I confirmed with my primary care and he said I could also do 1/2 pill for one week then stop. The reason I stopped it was because I wanted to see if the injection works for me. I received the injection last Friday, I usually get a headache on the weekend but nothing this past weekend so I am happy 😀

  3. And as for the as needed, he prescribed Ubrelvy. Is that a good one in your opinion? Thank you

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